Panobinostat phase 1 trial provides limited advance in HDAC inhibitor pipeline

The first clinical trial of Panobinostat by the Department of Infectious Diseases and Department of Immunology at Aarhus University Hospital, Denmark marks the next step in the development of the histone deactylase (HDAC) inhibitor group of latency reversal agents [1]. Thomas Rasmussen and colleagues describe results from this single-arm phase1/2 clinical trial of the second …

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Theo Smart’s Partial Publications/Portfolio list (a work in progress)

Major projects with published output accessible online, in order of the most recent (see end for freelance news coverage) Parent Project Muscular Dystrophy Medical writer: Submission of a Proposed Draft Guidance for Industry on Developing Drugs for Treatment of Duchenne Muscular Dystrophy; Establishment of a Public Docket (see here) Cover letter for submission: The Draft …

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The use of convalescent plasma or serum

Over the summer, an international network of blood regulators developed a physician’s paper for regulators, and for anyone who might wish to become involved, outlining the reasons to consider antibodies derived from blood or convalescent plasma, or ultimately, hyperimmune globulins as a potential therapy in a filovirus outbreak. They provided an assessment of the previous …

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Ebola vaccines in development

  The following table includes the leading candidates, however a number of these are not yet ready for a phase-1 trial but may be coming into trial over the next three to six months, and some are slightly longer term. Vaccine Manufacturers (developers): Vaccine details: Testing timeline: ChAd3-ZEBOV GlaxoSmithKline (National Institutes of Health (NIH) Chimpanzee …

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Experimental therapies being evaluated to treat Ebola

Experimental therapies for Ebola include new compounds, as well as existing drugs approved for other purposes which demonstrate activity in laboratory models and which potentially could be repurposed. At least something is known about the approved drug’s safety profile, though the doses used for Ebola may not be the same. Each of the following potential …

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WHO’s Comprehensive Plan to Rapidly Develop Therapeutics and Vaccines

Despite research into Ebola vaccines and therapeutics over the past decade, no product has been fully evaluated and approved for human use. This means that the only way to deal with this unprecedented outbreak has been to use the same basic public health and supportive care measures that were available in the past. Having an …

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Lessons learned in the ‘Hot Zone’

“The most difficult part for a clinician is when you don’t know if the patient has Ebola or not,” said Dr. Frederique Jacquerioz at the recent American Society of Tropical Medicine and Hygiene Meeting in New Orleans. Despite the title of her presentation ‘from the ‘Hot Zone’: A Clinician’s Perspective on Confronting Ebola Virus in …

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How did this Ebola outbreak emerge and what have we learned?

At the launch of the 2014 American Society of Tropical Medicine and Hygiene Conference in New Orleans, Bill Gates said the meeting was talking place at a critical moment in the history of global health — in the midst of an Ebola epidemic in a part of the world that had already been hit hard …

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Why has this Ebola outbreak been so large?

A recurring question about the current Ebola outbreak is how it grew to be so large — and whether the virus has changed modes of transmission or somehow become more infectious. However, most of the experts at the American Society of Tropical Medicine and Health conference held in New Orleans in early November agreed: The …

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